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Article

Correcting human mitochondrial mutations with targeted RNA import.

Proceedings of the National Academy of Sciences of the United States of America - 27 Mar 2012

Wang Geng, Shimada Eriko, Zhang Jin, Hong Jason S, Smith Geoffrey M, Teitell Michael A, Koehler Carla M

Abstract excerpt

Mutations in the human mitochondrial genome are implicated in neuromuscular diseases, metabolic defects, and aging. An efficient and simple mechanism for neutralizing deleterious mitochondrial DNA (mtDNA) alterations has unfortunately remained elusive. Here, we report that a 20-ribonucleotide stem-loop sequence from the H1 RNA, the RNA component of the human RNase P enzyme, appended to a nonimported RNA directs...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22411789
DOI: 10.1073/pnas.1116792109
PMCID: PMC3323963

Genes

MRPS12

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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