Article
Analysis of the human polynucleotide phosphorylase (PNPase) reveals differences in RNA binding and response to phosphate compared to its bacterial and chloroplast counterparts.
RNA (New York, N.Y.) - 1 Feb 2008
Portnoy Victoria, Palnizky Gili, Yehudai-Resheff Shlomit, Glaser Fabian, Schuster Gadi
Abstract excerpt
PNPase is a major exoribonuclease that plays an important role in the degradation, processing, and polyadenylation of RNA in prokaryotes and organelles. This phosphorolytic processive enzyme uses inorganic phosphate and nucleotide diphosphate for degradation and polymerization activities, respectively. Its structure and activities are similar to the archaeal exosome complex. The human PNPase was recently...
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