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Article

The atypical guanine nucleotide exchange factor Dock4 regulates neurite differentiation through modulation of Rac1 GTPase and actin dynamics.

The Journal of biological chemistry - 5 Jul 2013

Xiao Yangui, Peng Yinghui, Wan Jun, Tang Genyun, Chen Yuewen, Tang Jing, Ye Wen-Cai, Ip Nancy Y, Shi Lei

Abstract excerpt

Precise regulation of neurite growth and differentiation determines accurate formation of synaptic connections, whose disruptions are frequently associated with neurological disorders. Dedicator of cytokinesis 4 (Dock4), an atypical guanine nucleotide exchange factor for Rac1, is found to be associated with neuropsychiatric diseases, including autism and schizophrenia. Nonetheless, the neuronal function of Dock4...

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PMID: 23720743
DOI: 10.1074/jbc.M113.458612
PMCID: PMC3707701

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