Article
Palmitoylation controls DLK localization, interactions and activity to ensure effective axonal injury signaling.
Proceedings of the National Academy of Sciences of the United States of America - 19 Jan 2016
Holland Sabrina M, Collura Kaitlin M, Ketschek Andrea, Noma Kentaro, Ferguson Toby A, Jin Yishi, Gallo Gianluca, Thomas Gareth M
Abstract excerpt
Dual leucine-zipper kinase (DLK) is critical for axon-to-soma retrograde signaling following nerve injury. However, it is unknown how DLK, a predicted soluble kinase, conveys long-distance signals and why homologous kinases cannot compensate for loss of DLK. Here, we report that DLK, but not homologous kinases, is palmitoylated at a conserved site adjacent to its kinase domain. Using short-hairpin RNA...
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