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Article

A lipidation inhibitor rescues impaired neurite outgrowth caused by the CDC42 mutation associated with Takenouchi-Kosaki syndrome in Neuro2A cells.

Brain & development - 1 Feb 2026

Daimon Etsuko, Shibukawa Yukinao, Yamazaki Natsuko, Kawai Masanobu, Kinoshita Saori, Okamoto Nobuhiko

Abstract excerpt

BACKGROUND: Takenouchi-Kosaki syndrome (TKS), caused by the CDC42 c.191A>G (p.Tyr64Cys; Y64C) variant, characterized by a range of clinical manifestations, including developmental delay with intellectual disability (ID). While CDC42 is essential for neurogenesis, the mechanisms by which the Y64C mutation contributes to the neurological impairments observed in TKS patients remain unclear. OBJECTIVE: This study...

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Identifiers

PMID: 41581414
DOI: 10.1016/j.braindev.2026.104503

Genes

CDC42

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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