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Article

PTEN induces cell cycle arrest by decreasing the level and nuclear localization of cyclin D1.

Molecular and cellular biology - 1 Sept 2003

Radu Aurelian, Neubauer Valerie, Akagi Tsuyoshi, Hanafusa Hidesaburo, Georgescu Maria-Magdalena

Abstract excerpt

PTEN is a tumor suppressor frequently inactivated in brain, prostate, and uterine cancers that acts as a phosphatase on phosphatidylinositol-3,4,5-trisphosphate, antagonizing the activity of the phosphatidylinositol 3'-OH kinase. PTEN manifests its tumor suppressor function in most tumor cells by...

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Source

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Identifiers

PMID: 12917336
DOI: 10.1128/MCB.23.17.6139-6149.2003
PMCID: PMC180959

Genes

PTEN
CDK4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12917336-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

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PTEN induces cell cycle arrest by decreasing the level and nuclear localization of cyclin D1.PMID 12917336Read ↗

Cell cycle arrest by the PTEN tumor suppressor is target cell specific and may require protein phosphatase activity.Semantic proximity Read ↗

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PTEN: tumour suppressor, multifunctional growth regulator and more.Semantic proximity Read ↗

The phosphoinositol phosphatase activity of PTEN mediates a serum-sensitive G1 growth arrest in glioma cells.Semantic proximity Read ↗

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Attenuation of PTEN increases p21 stability and cytosolic localization in kidney cancer cells: a potential mechanism of apoptosis resistanceSemantic proximity Read ↗

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A short N-terminal sequence of PTEN controls cytoplasmic localization and is required for suppression of cell growth.Semantic proximity Read ↗

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