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Article

Role of the polybasic sequence in the Doc2alpha C2B domain in dense-core vesicle exocytosis in PC12 cells.

Journal of neurochemistry - 1 Jul 2010

Sato Mai, Mori Yasunori, Matsui Takahide, Aoki Ryo, Oya Manami, Yanagihara Yu, Fukuda Mitsunori, Tsuboi Takashi

Abstract excerpt

The double C2 (Doc2) family is characterized by an N-terminal Munc13-1-interacting domain and C-terminal tandem C2 domains, and it comprises three isoforms, Doc2alpha, Doc2beta, and Doc2gamma, in humans and mice. Doc2alpha, the best-characterized, brain-specific isoform, exhibits Ca(2+)-dependent phospholipid-binding activity through its C2A domain, and the Ca(2+)-binding activity is thought to be important for...

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Identifiers

PMID: 20403080
DOI: 10.1111/j.1471-4159.2010.06739.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Role of the polybasic sequence in the Doc2alpha C2B domain in dense-core vesicle exocytosis in PC12 cells.PMID 20403080Read ↗

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