Article
The additive effect of p53 Arg72Pro and RNASEL Arg462Gln genotypes on age of disease onset in Lynch syndrome patients with pathogenic germline mutations in MSH2 or MLH1.
Cancer letters - 8 Jul 2007
Krüger Stefan, Engel Christoph, Bier Andrea, Silber Ann-Sophie, Görgens Heike, Mangold Elisabeth, Pagenstecher Constanze, Holinski-Feder Elke, von Knebel Doeberitz Magnus, Royer-Pokora Brigitte, Dechant Stefan, Pox Christian, Rahner Nils, Müller Annegret, Schackert Hans K
Abstract excerpt
p53 and the prostate-cancer-susceptibility gene RNASEL are tumour suppressor genes involved in apoptosis. We have previously reported that the common, functionally different variants Arg72Pro in p53 and Arg462Gln in RNASEL are associated with the age of disease onset of colorectal cancer in Lynch syndrome patients. To assess the combined effect of both variants, we screened 246 unrelated Lynch syndrome patients...
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