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Article

Inactivation of fatty acid transport protein 1 prevents fat-induced insulin resistance in skeletal muscle.

The Journal of clinical investigation - 1 Mar 2004

Kim Jason K, Gimeno Ruth E, Higashimori Takamasa, Kim Hyo-Jeong, Choi Hyejeong, Punreddy Sandhya, Mozell Robin L, Tan Guo, Stricker-Krongrad Alain, Hirsch David J, Fillmore Jonathan J, Liu Zhen-Xiang, Dong Jianying, Cline Gary, Stahl Andreas, Lodish Harvey F, Shulman Gerald I

Abstract excerpt

Insulin resistance in skeletal muscle plays a major role in the development of type 2 diabetes and may be causally associated with increases in intramuscular fatty acid metabolites. Fatty acid transport protein 1 (FATP1) is an acyl-CoA synthetase highly expressed in skeletal muscle and modulates fatty acid uptake and metabolism by converting fatty acids into fatty acyl-CoA. To investigate the role of FATP1 in...

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Identifiers

PMID: 14991074
DOI: 10.1172/JCI18917
PMCID: PMC351314

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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