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Article

Krox20 stimulates adipogenesis via C/EBPbeta-dependent and -independent mechanisms.

Cell metabolism - 1 Feb 2005

Chen Zhu, Torrens Javier I, Anand Ashim, Spiegelman Bruce M, Friedman Jeffrey M

Abstract excerpt

Krox20 is a zinc finger-containing transcription factor that is abundantly expressed in adipose tissue. However, its role in fat cell differentiation has not been established. In cultured 3T3-L1 cells, Krox20 is rapidly induced by serum stimulation. Overexpression of Krox20 in both 3T3-L1 preadipocytes and multipotent NIH3T3 cells promotes adipogenesis in a hormone-dependent manner. Conversely, RNAi-mediated loss...

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Identifiers

PMID: 16054051
DOI: 10.1016/j.cmet.2004.12.009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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