Article
Srebf1a is a key regulator of transcriptional control for adipogenesis.
Scientific reports - 1 Jan 2011
Ayala-Sumuano Jorge-Tonatiuh, Velez-Delvalle Cristina, Beltrán-Langarica Alicia, Marsch-Moreno Meytha, Cerbón-Solorzano Jorge, Kuri-Harcuch Walid
Abstract excerpt
Adipogenesis is regulated by a complex cascade of transcriptional factors, but little is known about the early events that regulate the adipogenic program. Here, we report the role of the srebf1a gene in the differentiation of fibroblastic 3T3-F442A cells. We found that expression of srebf1a depended on GSK3β activity and that GSK3β activity was necessary for C/EBPβ phosphorylation at Thr188. Knockdown of srebf1a...
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