Article
Role of Krüppel-like factor 15 (KLF15) in transcriptional regulation of adipogenesis.
The Journal of biological chemistry - 1 Apr 2005
Mori Toshiyuki, Sakaue Hiroshi, Iguchi Haruhisa, Gomi Hideyuki, Okada Yuko, Takashima Yasuhiro, Nakamura Kyoko, Nakamura Takehiro, Yamauchi Toshimasa, Kubota Naoto, Kadowaki Takashi, Matsuki Yasushi, Ogawa Wataru, Hiramatsu Ryuji, Kasuga Masato
Abstract excerpt
Krüppel-like zinc finger transcription factors (KLFs) play diverse roles during cell differentiation and development in mammals. We have now shown by microarray analysis that expression of the KLF15 gene is markedly up-regulated during the differentiation of 3T3-L1 preadipocytes into adipocytes. Inhibition of the function of KLF15, either by expression of a dominant negative mutant or by RNA interference, both...
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