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Article

Identification of the transcription factor ZEB1 as a central component of the adipogenic gene regulatory network

26 Aug 2014

Abstract excerpt

Adipose tissue is a key determinant of whole body metabolism and energy homeostasis. Unraveling the regulatory mechanisms underlying adipogenesis is therefore highly relevant from a biomedical perspective. Our current understanding of fat cell differentiation is centered on the transcriptional cascades driven by the C/EBP protein family and the master regulator PPARγ. To elucidate further components of the...

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PMID: 25163748
DOI: 10.7554/elife.03346

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