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Article

AAV-mediated leptin receptor installation improves energy balance and the reproductive status of obese female Koletsky rats.

Peptides - 1 Dec 2005

Keen-Rhinehart Erin, Kalra Satya P, Kalra Pushpa S

Abstract excerpt

Leptin is a hormone secreted primarily by white adipocytes that regulates energy homeostasis and reproduction via CNS receptors. Koletsky (f/f) rats with a leptin receptor (OB-Rb) gene mutation are obese, diabetic and infertile. We employed recombinant adeno-associated viral (rAAV) vectors to transfer the human OB-Rb gene into the brains of female Koletsky rats to identify sites of leptin action in the brain....

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Source

Identifiers

PMID: 16024137
DOI: 10.1016/j.peptides.2005.05.027

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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