Article
Molecular determinants of sensitivity and conductivity of human TRPM7 to Mg2+ and Ca2+.
Channels (Austin, Tex.) - 1 Jan 2000
Numata Tomohiro, Okada Yasunobu
Abstract excerpt
It is known that extracellular Mg(2+) and Ca(2+) can permeate TRPM7 and at the same time block the permeation by monovalent cations. In the present study, we examined the molecular basis for the conductivity and sensitivity of human TRPM7 to these divalent cations. Extracellular acidification to pH 4.0 markedly reduced the blocking effects of Mg(2+) and Ca(2+) on the Cs(+) currents, decreasing their binding...
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