Article
The centrosomal protein CP190 regulates myosin function during early Drosophila development.
Current biology : CB - 26 Jul 2005
Chodagam S, Royou A, Whitfield W, Karess R, Raff J W
Abstract excerpt
Centrosomes are the main microtubule (MT)-organizing centers in animal cells, but they also influence the actin/myosin cytoskeleton. The Drosophila CP190 protein is nuclear in interphase, interacts with centrosomes during mitosis, and binds to MTs directly in vitro. CP190 has an essential function in the nucleus as a chromatin insulator, but centrosomes and MTs appear unperturbed in Cp190 mutants. Thus, the...
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