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CEP250 is Required for Maintaining Centrosome Cohesion in the Germline and Fertility in Male Mice

19 Jan 2022

Abstract excerpt

Male gametogenesis involves both mitotic divisions to amplify germ cell progenitors that gradually differentiate and meiotic divisions. Centrosomal regulation is essential for both types of divisions, with centrioles remaining tightly paired during the interphase. Here, we generated and characterized the phenotype of mutant mice devoid of Cep250/C-Nap1, a gene encoding for a docking protein for fibers linking...

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PMID: 35127699
DOI: 10.3389/fcell.2021.754054

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