Article
Deletion of LTbetaR augments male susceptibility to Plasmodium chabaudi.
Parasite immunology - 1 Jun 2005
Krücken J, Braun J V, Dkhil M A, Grunwald A, Wunderlich F
Abstract excerpt
SUMMARY Disruption of the lymphotoxin beta receptor (LTbetaR) gene has been shown to result in enhanced resistance of female mice to blood-stage Plasmodium chabaudi malaria. Here, we investigate the effect of LTbetaR deletion on host defence of males. In contrast to females, male LTbetaR(-/-) mice do not exhibit any increase in resistance. Conversely, they are even more susceptible than wild-type C57BL/6 mice,...
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