Article
Testosterone and other gonadal factor(s) restrict the efficacy of genes controlling resistance to Plasmodium chabaudi malaria.
Parasite immunology - 1 Jul 1991
Wunderlich F, Marinovski P, Benten W P, Schmitt-Wrede H P, Mossmann H
Abstract excerpt
The effect of circulating concentrations of testosterone (Te) on resistance to Plasmodium chabaudi malaria was investigated in the H-2 congenic mouse strains C57BL/10, B10.A, B10.A(3R), B10.A(4R), and B10.D2. Te-levels were determined by radioimmunoassay and resistance was expressed in terms of percent self-healers after challenge with 10(6) P. chabaudi-infected erythrocytes. Our data indicate: (i) Females and...
Topics
- Alleles
- Animals
- Buserelin
- Disease Susceptibility
- Female
- H-2 Antigens
- Immunity, Innate
- Malaria
- Male
- Mice
- Mice, Inbred C57BL
- Orchiectomy
