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Article

Targeting Angiotensin II Type-1 Receptor (AT1R) Inhibits the Harmful Phenotype of Plasmodium-Specific CD8+ T Cells during Blood-Stage Malaria.

Frontiers in cellular and infection microbiology - 1 Jan 2017

Silva-Filho João L, Caruso-Neves Celso, Pinheiro Ana A S

Abstract excerpt

CD8+ T-cell response is critical in the pathogenesis of cerebral malaria during blood-stage. Our group and other have been shown that angiotensin II (Ang II) and its receptor AT1 (AT1R), a key effector axis of renin-angiotensin system (RAS), have immune regulatory effects on T cells. Previously, we showed that inhibition of AT1R signaling protects mice against the lethal disease induced by Plasmodium berghei ANKA...

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Identifiers

PMID: 28261571
DOI: 10.3389/fcimb.2017.00042
PMCID: PMC5311040

Genes

ACE
CCR5
CXCR3
TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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