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Article

TREM2 governs Kupffer cell activation and explains belr1 genetic resistance to malaria liver stage infection.

Proceedings of the National Academy of Sciences of the United States of America - 26 Nov 2013

Gonçalves Lígia Antunes, Rodrigues-Duarte Lurdes, Rodo Joana, Vieira de Moraes Luciana, Marques Isabel, Penha-Gonçalves Carlos

Abstract excerpt

Plasmodium liver stage infection is a target of interest for the treatment of and vaccination against malaria. Here we used forward genetics to search for mechanisms underlying natural host resistance to infection and identified triggering receptor expressed on myeloid cells 2 (TREM2) and MHC class II molecules as determinants of Plasmodium berghei liver stage infection in mice. Locus belr1 confers resistance to...

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Share to Genetic Loci
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Kupffer Cells

Share to Malaria

Share to Membrane Glycoproteins

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Share to Receptors, Immunologic

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Source

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Identifiers

PMID: 24218563
DOI: 10.1073/pnas.1306873110
PMCID: PMC3845107

Genes

TREM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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