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Article

Exposing the co-adaptive potential of protein-protein interfaces through computational sequence design.

Bioinformatics (Oxford, England) - 15 Sept 2010

Fromer Menachem, Linial Michal

Abstract excerpt

MOTIVATION: In nature, protein-protein interactions are constantly evolving under various selective pressures. Nonetheless, it is expected that crucial interactions are maintained through compensatory mutations between interacting proteins. Thus, many studies have used evolutionary sequence data to extract such occurrences of correlated mutation. However, this research is confounded by other evolutionary...

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PMID: 20679332
DOI: 10.1093/bioinformatics/btq412

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