Article

Pyruvate Kinase M1 Regulates Butyrate Metabolism in Cancerous Colonocytes

2021-12-01

Abstract excerpt

Colorectal cancer (CRC) cells shift metabolism toward aerobic glycolysis and away from using oxidative substrates such as butyrate. Pyruvate kinase M1/2 (PKM) is an enzyme that catalyzes the last step in glycolysis, which converts phosphoenolpyruvate to pyruvate. M1 and M2 are alternatively spliced isoforms of the Pkm gene. The PKM1 isoform promotes oxidative metabolism, whereas PKM2 enhances aerobic glycolysis. W...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 087921f3-4db5-5728-8148-639d99092bd5
DOI: 10.21203/rs.3.rs-1097223/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Pyruvate Kinase M1 Regulates Butyrate Metabolism in Cancerous ColonocytesDOI 10.21203/rs.3.rs-1097223/v1Read

Metabolism‐Based Molecular Subtyping Endows Effective Ketogenic Therapy in p53‐Mutant Colon CancerSemantic proximity Read

Energy Metabolism Profiling of Human Colorectal TumoursSemantic proximity Read

A novel lncRNA 495810 promotes the aerobic glycolysis in colorectal cancer by stabilizing pyruvate kinase isozyme M2Semantic proximity Read

Colorectal polyps increase the glycolytic activitySemantic proximity Read

Targeting Altered Energy Metabolism in Colorectal Cancer: Oncogenic Reprogramming, the Central Role of the TCA Cycle and Therapeutic OpportunitiesSemantic proximity Read

Glycolysis gene expression analysis and selective metabolic advantage in the clinical progression of colorectal cancer.Semantic proximity Read

Characterization of butyrate-metabolism in colorectal cancer to guide clinical treatmentSemantic proximity Read

Role of SCFAs in gut microbiome and glycolysis for colorectal cancer therapySemantic proximity Read

Wild-type IDH1 Knockout Leads to G0/G1 Arrest, Impairs Cancer Cell Proliferation, Altering Glycolysis, and the TCA Cycle in Colon Cancer.Semantic proximity Read

Creatine kinase mitochondrial 2 promotes the growth and progression of colorectal cancer via enhancing Warburg effect through lactate dehydrogenase BSemantic proximity Read

The Role of PKM2 in Metabolic Reprogramming: Insights into the Regulatory Roles of Non-Coding RNAs.Semantic proximity Read

Vitamin C uncouples the Warburg metabolic switch in KRAS mutant colon cancer.Semantic proximity Read