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Butyrate Produced by Commensal Bacteria Down-Regulates Indolamine 2,3-Dioxygenase 1 (IDO-1) Expression via a Dual Mechanism in Human Intestinal Epithelial Cells

11 Dec 2018

Abstract excerpt

Commensal bacteria are crucial for the development and maintenance of a healthy immune system therefore contributing to the global wellbeing of their host. A wide variety of metabolites produced by commensal bacteria are influencing host health but the characterisation of the multiple molecular mechanisms involved in host-microbiota interactions is still only partially unravelled. The intestinal epithelial cells...

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PMID: 30619249
DOI: 10.3389/fimmu.2018.02838

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