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Article

Influence of ABCB1, ABCC1, ABCC2, and ABCG2 haplotypes on the cellular exposure of nelfinavir in vivo.

Pharmacogenetics and genomics - 1 Sept 2005

Colombo Sara, Soranzo Nicole, Rotger Margalida, Sprenger Raimund, Bleiber Gabriela, Furrer Hansjakob, Buclin Thierry, Goldstein David, Décosterd Laurent, Telenti Amalio

Abstract excerpt

OBJECTIVES: The human immunodeficiency virus protease inhibitor nelfinavir is substrate of polyspecific drug transporters encoded by ABCB1 (P-glycoprotein), ABCC1 (MRP1) and ABCC2 (MRP2), and an inhibitor of BCRP, encoded by ABCG2. Genetic polymorphism in these genes may be associated with changes in transport function. METHODS: A comprehensive evaluation of single nucleotide polymorphisms (39 SNPs in ABCB1, 7 in...

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Source

Identifiers

PMID: 16041239
DOI: 10.1097/01.fpc.0000172241.42546.d3

Genes

ABCB1
ABCC1
ABCC2
ABCG2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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