Article
Role for nucleotide excision repair in virulence of Mycobacterium tuberculosis.
Infection and immunity - 1 Aug 2005
Darwin K Heran, Nathan Carl F
Abstract excerpt
Mutations in Mycobacterium tuberculosis uvrB result in severe sensitivity to acidified nitrite, a source of nitric oxide (6). In this study, we show that a uvrB mutant is exquisitely sensitive to UV light but not to several sources of reactive oxygen species in vitro. Furthermore, a uvrB mutant was attenuated in mice as judged by an extension of life span. Attenuation in mice was partially reversed by genetic...
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