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Article

Mycobacterium tuberculosis Lsr2 is a global transcriptional regulator required for adaptation to changing oxygen levels and virulence.

mBio - 3 Jun 2014

Bartek I L, Woolhiser L K, Baughn A D, Basaraba R J, Jacobs W R, Lenaerts A J, Voskuil M I

Abstract excerpt

UNLABELLED: To survive a dynamic host environment, Mycobacterium tuberculosis must endure a series of challenges, from reactive oxygen and nitrogen stress to drastic shifts in oxygen availability. The mycobacterial Lsr2 protein has been implicated in reactive oxygen defense via direct protection of DNA. To examine the role of Lsr2 in pathogenesis and physiology of M. tuberculosis, we generated a strain deleted...

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Identifiers

PMID: 24895305
DOI: 10.1128/mBio.01106-14
PMCID: PMC4049101

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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