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Article

Actin cytoskeleton disruption by ExoY and its effects on Pseudomonas aeruginosa invasion.

FEMS microbiology letters - 1 Sept 2005

Cowell Brigitte A, Evans David J, Fleiszig Suzanne M J

Abstract excerpt

Three of the Type III-secreted effectors of Pseudomonas aeruginosa (ExoS, ExoT, and ExoY) each alter mammalian cell morphology in culture without causing a loss of cell viability. For ExoS and ExoT this property involves RhoGAP activity, and leads to actin cytoskeleton disruption and a reduced capacity for internalizing bacteria. ExoY does not possess RhoGAP activity. Instead, cell rounding depends upon its...

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Identifiers

PMID: 16039071
DOI: 10.1016/j.femsle.2005.06.044

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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