Actin cytoskeleton disruption by ExoY and its effects on Pseudomonas aeruginosa invasion.

doi:10.1016/j.femsle.2005.06.044

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Article

Actin cytoskeleton disruption by ExoY and its effects on Pseudomonas aeruginosa invasion.

FEMS microbiology letters - 1 Sept 2005

Cowell Brigitte A, Evans David J, Fleiszig Suzanne M J

Abstract excerpt

Three of the Type III-secreted effectors of Pseudomonas aeruginosa (ExoS, ExoT, and ExoY) each alter mammalian cell morphology in culture without causing a loss of cell viability. For ExoS and ExoT this property involves RhoGAP activity, and leads to actin cytoskeleton disruption and a reduced capacity for internalizing bacteria. ExoY does not possess RhoGAP activity. Instead, cell rounding depends upon its...

Topics

Actins
Animals
Bacterial Proteins
Catalytic Domain
Cells, Cultured
Cytoskeleton
Epithelial Cells
Genes, Bacterial
Glucosyltransferases
Mutation
Pseudomonas aeruginosa
Rabbits
Virulence

Source

Open in PubMed

Identifiers

PMID: 16039071
DOI: 10.1016/j.femsle.2005.06.044

Provenance

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