Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutation of lasA and lasB reduces Pseudomonas aeruginosa invasion of epithelial cells.

Microbiology (Reading, England) - 1 Aug 2003

Cowell Brigitte A, Twining Sally S, Hobden Jeffrey A, Kwong Mary S F, Fleiszig Suzanne M J

Abstract excerpt

Pseudomonas aeruginosa is an opportunistic bacterial pathogen implicated in a variety of devastating conditions. Its flexibility as a pathogen is attributed to a myriad of virulence factors and regulatory elements that respond to prevailing environmental conditions. ExoS and ExoT are type III secreted effector proteins, regulated by the transcriptional activator ExsA, that can inhibit invasion of epithelial cells...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to ADP Ribose Transferases
Share to Bacterial Toxins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Caseins

Share to Elastin

Share to Endopeptidases

Share to GTPase-Activating Proteins

Share to Metalloendopeptidases

Share to Rabbits

Source

Identifiers

PMID: 12904569
DOI: 10.1099/mic.0.26280-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutation of lasA and lasB reduces Pseudomonas aeruginosa invasion of epithelial cells.PMID 12904569Read ↗

Quorum-sensing inhibition abrogates the deleterious impact of Pseudomonas aeruginosa on airway epithelial repair.Semantic proximity Read ↗

ExoS and ExoT ADP Ribosyltransferase Activities Mediate Pseudomonas aeruginosa Keratitis by Promoting Neutrophil Apoptosis and Bacterial SurvivalSemantic proximity Read ↗

ExoU Induces Lung Endothelial Cell Damage and Activates Pro-Inflammatory Caspase-1 during Pseudomonas aeruginosa Infection.Semantic proximity Read ↗

Quorum sensing-dependent post-secretional activation of extracellular proteases in Pseudomonas aeruginosa.Semantic proximity Read ↗

Alveolar Response toPseudomonas aeruginosa: Role of the Type III Secretion SystemSemantic proximity Read ↗

Exotoxin S secreted by internalized Pseudomonas aeruginosa delays lytic host cell death.Semantic proximity Read ↗

Secreted LasA of Pseudomonas aeruginosa is a staphylolytic protease.Semantic proximity Read ↗

ExoU expression by Pseudomonas aeruginosa correlates with acute cytotoxicity and epithelial injury.Semantic proximity Read ↗

Characterization of cell-to-cell signaling-deficient Pseudomonas aeruginosa strains colonizing intubated patients.Semantic proximity Read ↗

Activities of Pseudomonas aeruginosa effectors secreted by the Type III secretion system in vitro and during infection.Semantic proximity Read ↗

Pseudomonas aeruginosa elastase provides an escape from phagocytosis by degrading the pulmonary surfactant protein-A.Semantic proximity Read ↗

Triggering the ExoS regulon of Pseudomonas aeruginosa: A GFP-reporter analysis of exoenzyme (Exo) S, ExoT and ExoU synthesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.