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Article

Exotoxin S secreted by internalized Pseudomonas aeruginosa delays lytic host cell death.

PLoS pathogens - 1 Feb 2022

Kroken Abby R, Gajenthra Kumar Naren, Yahr Timothy L, Smith Benjamin E, Nieto Vincent, Horneman Hart, Evans David J, Fleiszig Suzanne M J

Abstract excerpt

The Pseudomonas aeruginosa toxin ExoS, secreted by the type III secretion system (T3SS), supports intracellular persistence via its ADP-ribosyltransferase (ADPr) activity. For epithelial cells, this involves inhibiting vacuole acidification, promoting vacuolar escape, countering autophagy, and niche construction in the cytoplasm and within plasma membrane blebs. Paradoxically, ExoS and other P. aeruginosa T3SS...

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Share to ADP Ribose Transferases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 35130333
DOI: 10.1371/journal.ppat.1010306
PMCID: PMC8853526

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