Article
Independent and coordinate effects of ADP-ribosyltransferase and GTPase-activating activities of exoenzyme S on HT-29 epithelial cell function.
Infection and immunity - 1 Sept 2001
Fraylick J E, La Rocque J R, Vincent T S, Olson J C
Abstract excerpt
Type III-mediated translocation of exoenzyme S (ExoS) into HT-29 epithelial cells by Pseudomonas aeruginosa causes complex alterations in cell function, including inhibition of DNA synthesis, altered cytoskeletal structure, loss of readherence, microvillus effacement, and interruption of signal transduction. ExoS is a bifunctional protein having both GTPase-activating (GAP) and ADP-ribosyltransferase (ADPRT)...
Topics
- ADP Ribose Transferases
- Bacterial Toxins
- Cell Division
- Cell Size
- DNA
- GTP Phosphohydrolases
- Gene Expression Regulation, Bacterial
- HT29 Cells
- Humans
- Mutation
- Poly(ADP-ribose) Polymerases
- Pseudomonas aeruginosa
- ras Proteins