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Article

A gene signature identified using a mouse model of androgen receptor-dependent prostate cancer predicts biochemical relapse in human disease.

International journal of cancer - 1 Aug 2012

Thompson Vanessa C, Day Tanya K, Bianco-Miotto Tina, Selth Luke A, Han Guangzhou, Thomas Mervyn, Buchanan Grant, Scher Howard I, Nelson Colleen C, Greenberg Norman M, Butler Lisa M, Tilley Wayne D

Abstract excerpt

Mutations in the androgen receptor (AR) have been detected in experimental and clinical prostate tumors. Mice with enforced prostate-specific expression of one such receptor variant, AR-E231G, invariably develop prostatic intraepithelial neoplasia by 12 weeks and metastatic prostate cancer by 52 weeks. The aim of this study was to identify genes with altered expression in the prostates of AR-E231G mice at an...

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PMID: 22275114
DOI: 10.1002/ijc.26414

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ADM
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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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