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Article

NK cell activation in visceral leishmaniasis requires TLR9, myeloid DCs, and IL-12, but is independent of plasmacytoid DCs.

The Journal of experimental medicine - 16 Apr 2007

Schleicher Ulrike, Liese Jan, Knippertz Ilka, Kurzmann Claudia, Hesse Andrea, Heit Antje, Fischer Jens A A, Weiss Siegfried, Kalinke Ulrich, Kunz Stefanie, Bogdan Christian

Abstract excerpt

Natural killer (NK) cells are sentinel components of the innate response to pathogens, but the cell types, pathogen recognition receptors, and cytokines required for their activation in vivo are poorly defined. Here, we investigated the role of plasmacytoid dendritic cells (pDCs), myeloid DCs (mDCs), Toll-like receptors (TLRs), and of NK cell stimulatory cytokines for the induction of an NK cell response to the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17389237
DOI: 10.1084/jem.20061293
PMCID: PMC2118560

Genes

TLR9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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