Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dendritic cell maturation by CD11c- T cells and Valpha24+ natural killer T-cell activation by alpha-galactosylceramide.

International journal of cancer - 1 Nov 2005

Ishikawa Eiichi, Motohashi Shinichiro, Ishikawa Aki, Ito Toshihiro, Uchida Tetsuro, Kaneko Takaaki, Tanaka Yuriko, Horiguchi Shigetoshi, Okamoto Yoshitaka, Fujisawa Takehiko, Tsuboi Koji, Taniguchi Masaru, Matsumura Akira, Nakayama Toshinori

Abstract excerpt

Human invariant Valpha24+ natural killer T (NKT) cells display potent antitumor activity upon stimulation. Activation of endogenous Valpha24+ NKT cells would be one strategy for the treatment of cancer patients. For example, dendritic cells (DCs) loaded with a glycolipid NKT cell ligand, alpha-galactosylceramide (alphaGalCer, KRN7000), are a possible tool for the activation and expansion of functional Valpha24+...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CD11c Antigen
Share to Cytotoxicity, Immunologic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dendritic Cells

Share to Granulocyte-Macrophage Colony-Stimulating Factor

Share to Immunotherapy

Share to Interferon-gamma

Share to Interleukin-2

Share to Killer Cells, Natural

Source

Identifiers

PMID: 15900581
DOI: 10.1002/ijc.21197

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dendritic cell maturation by CD11c- T cells and Valpha24+ natural killer T-cell activation by alpha-galactosylceramide.PMID 15900581Read ↗

Human invariant Valpha24+ natural killer T cells acquire regulatory functions by interacting with IL-10-treated dendritic cells.Semantic proximity Read ↗

In vitro anti-tumour activity of alpha-galactosylceramide-stimulated human invariant Valpha24+NKT cells against melanoma.Semantic proximity Read ↗

Th1-polarizing capacity of clinical-grade dendritic cells is triggered by Ribomunyl but is compromised by PGE2: the importance of maturation cocktails.Semantic proximity Read ↗

Effective induction of melanoma-antigen-specific CD8+ T cells via Vγ9γδT cell expansion by CD56(high+) Interferon-α-induced dendritic cells.Semantic proximity Read ↗

Cytokine production and migration of in vitro-expanded NK1.1(-) invariant Valpha14 natural killer T (Valpha14i NKT) cells using alpha-galactosylceramide and IL-2.Semantic proximity Read ↗

IFN-alpha in the generation of dendritic cells for cancer immunotherapy.Semantic proximity Read ↗

Human dendritic cells engineered to express alpha tumor necrosis factor maintain cellular maturation and T-cell stimulation capacity.Semantic proximity Read ↗

Different In Vitro-Generated MUTZ-3-Derived Dendritic Cell Types Secrete Dexosomes with Distinct Phenotypes and Antigen Presentation Potencies.Semantic proximity Read ↗

Dendritic cells combined with tumor cells and α-galactosylceramide induce a potent, therapeutic and NK-cell dependent antitumor immunity in B cell lymphoma.Semantic proximity Read ↗

Interferon alpha induces generation of semi-mature dendritic cells with high pro-inflammatory and cytotoxic potential.Semantic proximity Read ↗

Interferon gamma stimulates cellular maturation of dendritic cell line DC2.4 leading to induction of efficient cytotoxic T cell responses and antitumor immunity.Semantic proximity Read ↗

Utilizing the adjuvant properties of CD1d-dependent NK T cells in T cell-mediated immunotherapy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.