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Article

Adaptive changes in the transcription factor HoxA-11 are essential for the evolution of pregnancy in mammals

22 Sept 2008

Abstract excerpt

Evolutionary change in gene regulation can result from changes in cis-regulatory elements, leading to differences in the temporal and spatial expression of genes or in the coding region of transcription factors leading to novel functions or both. Although there is a growing body of evidence supporting the importance of cis-regulatory evolution, examples of protein-mediated evolution of novel developmental...

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PMID: 18809929
DOI: 10.1073/pnas.0802355105

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