Article
Loss of function but no gain of function caused by amino acid substitutions in the hexapeptide of Hoxa1 in vivo.
Molecular and cellular biology - 1 Oct 2004
Remacle Sophie, Abbas Leïla, De Backer Olivier, Pacico Nathalie, Gavalas Anthony, Gofflot Françoise, Picard Jacques J, Rezsöhazy René
Abstract excerpt
Homeodomain containing transcription factors of the Hox family play critical roles in patterning the anteroposterior embryonic body axis, as well as in controlling several steps of organogenesis. Several Hox proteins have been shown to cooperate with members of the Pbx family for the recognition and activation of identified target enhancers. Hox proteins contact Pbx via a conserved hexapeptide motif. Previous...
Topics
- Amino Acid Substitution
- Animals
- Body Patterning
- Cranial Nerves
- Ear
- Homeodomain Proteins
- Mice
- Mice, Transgenic
- Mutation
- Neural Crest
- Occipital Bone
- Peptide Fragments
- Rhombencephalon
- Transcription Factors