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Article

ARX: a gene for all seasons.

Current opinion in genetics & development - 1 Jun 2006

Gécz Jozef, Cloosterman Desiree, Partington Michael

Abstract excerpt

The Aristaless-related homeobox gene, ARX, is an important transcription factor with a crucial role in forebrain, pancreas and testes development. At least fifty-nine mutations have been described in the ARX gene in seven X-chromosome linked disorders involving mental retardation. Recent studies with ARX screening suggest that the gene is mutated in 9.5% of X-linked families with these disorders. Two different...

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Identifiers

PMID: 16650978
DOI: 10.1016/j.gde.2006.04.003

Genes

ARX

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

ARX: a gene for all seasons.PMID 16650978Read ↗

The role of ARX in cortical development.Semantic proximity Read ↗

ARX, a novel Prd-class-homeobox gene highly expressed in the telencephalon, is mutated in X-linked mental retardation.Semantic proximity Read ↗

Opposing actions of Arx and Pax4 in endocrine pancreas development.Semantic proximity Read ↗

Aristaless-related homeobox gene, the gene responsible for West syndrome and related disorders, is a Groucho/transducin-like enhancer of split dependent transcriptional repressor.Semantic proximity Read ↗

ARX spectrum disorders: making inroads into the molecular pathology.Semantic proximity Read ↗

Mutations in the human ortholog of Aristaless cause X-linked mental retardation and epilepsy.Semantic proximity Read ↗

The ARX story (epilepsy, mental retardation, autism, and cerebral malformations): one gene leads to many phenotypes.Semantic proximity Read ↗

The aristaless (Arx) gene: one gene for many "interneuronopathies".Semantic proximity Read ↗

Mouse orthologue of ARX, a gene mutated in several X-linked forms of mental retardation and epilepsy, is a marker of adult neural stem cells and forebrain GABAergic neurons.Semantic proximity Read ↗

The function of the Aristaless-related homeobox (Arx) gene product as a transcriptional repressor is diminished by mutations associated with X-linked mental retardation (XLMR).Semantic proximity Read ↗

[ARX--one gene--many phenotypes].Semantic proximity Read ↗

Arx is required for normal enteroendocrine cell development in mice and humansSemantic proximity Read ↗

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