Article
Mutations in the DnaA binding sites of the replication origin of Escherichia coli.
Molecular & general genetics : MGG - 1 May 1992
Holz A, Schaefer C, Gille H, Jueterbock W R, Messer W
Abstract excerpt
Mutations (base changes) were introduced into the four DnaA binding sites (DnaA boxes) of the Escherichia coli replication origin, oriC. Mutations in a single DnaA box did not impair the ability of these origins to replicate in vivo and in vitro. A combination of mutations in two DnaA boxes, R1 and R4, resulted in slower growth of the oriC plasmid-bearing host cells. DnaA protein interaction with mutant and...
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