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Article

Efficient RNA interference in zebrafish embryos using siRNA synthesized with SP6 RNA polymerase.

Development, growth & differentiation - 1 Jun 2005

Liu Wei-Yi, Wang Yan, Sun Yong-Hua, Wang Yun, Wang Ya-Ping, Chen Shang-Ping, Zhu Zuo-Yan

Abstract excerpt

Double-stranded RNA (dsRNA) has been shown to be a useful tool for silencing genes in zebrafish (Danio rerio), while the blocking specificity of dsRNA is still of major concern for application. It was reported that siRNA (small interfering RNA) prepared by endoribonuclease digestion (esiRNA) could efficiently silence endogenous gene expression in mammalian embryos. To test whether esiRNA could work in zebrafish,...

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Identifiers

PMID: 16026540
DOI: 10.1111/j.1440-169X.2005.00807.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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