Double-stranded RNA injection produces null phenotypes in zebrafish.

doi:10.1006/dbio.1999.9540

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Article

Double-stranded RNA injection produces null phenotypes in zebrafish.

Developmental biology - 15 Jan 2000

Li Y X, Farrell M J, Liu R, Mohanty N, Kirby M L

Abstract excerpt

Zebrafish is a simple vertebrate that has many attributes that make it ideal for the study of developmental genetics. One feature that has been lacking in this model system is the ability to disable specifically targeted genes. Recently, double-stranded RNA has been used to silence gene expression in the nematode Caenorhabditis elegans. We have found that expression of the green fluorescent protein (GFP) from a...

Topics

Animals
DNA-Binding Proteins
Dose-Response Relationship, Drug
Embryology
Eye Proteins
Fetal Proteins
Gene Expression Regulation, Developmental
Gene Silencing
Genes, Reporter
Genetic Techniques
Green Fluorescent Proteins
Hedgehog Proteins
Homeodomain Proteins

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

In Situ Hybridization

Luminescent Proteins

Microinjections

PAX6 Transcription Factor

Paired Box Transcription Factors

Source

Open in PubMed

Identifiers

PMID: 10625563
DOI: 10.1006/dbio.1999.9540

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