Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Double-stranded RNA injection produces null phenotypes in zebrafish.

Developmental biology - 15 Jan 2000

Li Y X, Farrell M J, Liu R, Mohanty N, Kirby M L

Abstract excerpt

Zebrafish is a simple vertebrate that has many attributes that make it ideal for the study of developmental genetics. One feature that has been lacking in this model system is the ability to disable specifically targeted genes. Recently, double-stranded RNA has been used to silence gene expression in the nematode Caenorhabditis elegans. We have found that expression of the green fluorescent protein (GFP) from a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brachyury Protein
Share to Fetal Proteins
Share to Microinjections

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Paired Box Transcription Factors

Share to PAX6 Transcription Factor

Share to RNA, Double-Stranded

Share to T-Box Domain Proteins

Source

Identifiers

PMID: 10625563
DOI: 10.1006/dbio.1999.9540

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Double-stranded RNA injection produces null phenotypes in zebrafish.PMID 10625563Read ↗

Double-stranded RNA induces specific developmental defects in zebrafish embryos.Semantic proximity Read ↗

Too much interference: injection of double-stranded RNA has nonspecific effects in the zebrafish embryo.Semantic proximity Read ↗

Using zinc finger nucleases for efficient and heritable gene disruption in zebrafish.Semantic proximity Read ↗

Reverse Genetics in Zebrafish: Mutants, Morphants, and Moving Forward.Semantic proximity Read ↗

Inducing high rates of targeted mutagenesis in zebrafish using zinc finger nucleases (ZFNs).Semantic proximity Read ↗

Saving zebrafish mutants.Semantic proximity Read ↗

Controlling morpholino experiments: don't stop making antisense.Semantic proximity Read ↗

Generating loss-of-function phenotypes of the fushi tarazu gene with a targeted ribozyme in Drosophila.Semantic proximity Read ↗

Use of fully modified 2'-O-methyl antisense oligos for loss-of-function studies in vertebrate embryos.Semantic proximity Read ↗

Efficient RNA interference in zebrafish embryos using siRNA synthesized with SP6 RNA polymerase.Semantic proximity Read ↗

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans.Semantic proximity Read ↗

Spatial and temporal 'knock down' of gene expression by electroporation of double-stranded RNA and morpholinos into early postimplantation mouse embryos.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.