Article
Selection strength and hitchhiking around two anti-malarial resistance genes.
Proceedings. Biological sciences - 7 Jun 2005
Nash Denae, Nair Shalini, Mayxay Mayfong, Newton Paul N, Guthmann Jean-Paul, Nosten François, Anderson Tim J C
Abstract excerpt
Neutral mutations may hitchhike to high frequency when they are situated close to sites under positive selection, generating local reductions in genetic diversity. This process is thought to be an important determinant of levels of genomic variation in natural populations. The size of genome regions affected by genetic hitchhiking is expected to be dependent on the strength of selection, but there is little...
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