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Article

Effects of the CYP3A5 genetic polymorphism on the pharmacokinetics of diltiazem.

Clinica chimica acta; international journal of clinical chemistry - 1 Dec 2005

Yamamoto Takehito, Kubota Takahiro, Ozeki Takeshi, Sawada Mika, Yokota Shin-ichi, Yamada Yasuhiko, Kumagai Yuji, Iga Tatsuji

Abstract excerpt

BACKGROUND: The cytochrome P450 (CYP) 3A subfamily plays an important role in the metabolism of various endogenous and exogenous compounds. Among CYP3A subfamily members, CYP3A5 is polymorphically expressed and the CYP3A5*3 and CYP3A5*6 alleles are known not to express functional CYP3A5. Thus, these mutant alleles are thought to be responsible for interindividual variability of CYP3A activity. METHODS: Subjects...

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Identifiers

PMID: 16024008
DOI: 10.1016/j.cccn.2005.06.013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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