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Article

Effect of CYP3A5*3 genotype on serum carbamazepine concentrations at steady-state in Korean epileptic patients.

Journal of clinical pharmacy and therapeutics - 1 Oct 2009

Park P-W, Seo Y H, Ahn J Y, Kim K-A, Park J-Y

Abstract excerpt

BACKGROUND AND OBJECTIVE: Carbamazepine (CBZ) is metabolized mainly by the CYP3A family of enzymes, which includes CYP3A4 and CYP3A5. Several studies have suggested that the CYP3A5*3 genotype influences the pharmacokinetics of CYP3A substrates. The present study aimed to assess the effect of the CYP3A5*3 genotype on serum concentration of CBZ at the steady-state in Korean epileptic patients. METHOD: The serum...

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Identifiers

PMID: 19744012
DOI: 10.1111/j.1365-2710.2009.01057.x

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