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Article

Effects of the CYP3A5 genotype on omeprazole sulfoxidation in CYP2C19 PMs.

European journal of clinical pharmacology - 1 Jun 2008

Sugimoto Katsuyoshi, Uno Tsukasa, Tateishi Tomonori

Abstract excerpt

OBJECTIVE: Omeprazole is metabolized by the two cytochrome P450 isoforms, CYP3A (sulfoxidation) and CYP2C 19 (hydroxydation). The aim of this study was to determine whether the CYP3A5 genotype is an important determinant of inter-individual variability of total CYP3A activity in vivo. METHODS: Plasma levels of omeprazole and omeprazole sulfone were analyzed by high-performance liquid chromatography in blood...

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Source

Identifiers

PMID: 18214455
DOI: 10.1007/s00228-008-0461-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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