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The disposition of three phosphodiesterase type 5 inhibitors, vardenafil, sildenafil, and udenafil, is differently influenced by the CYP3A5 genotype.

Pharmacogenetics and genomics - 1 Dec 2011

Shon Ji-Hong, Ku Hei-Young, Bae Seol-Youn, Oh Min-Kyung, Yeo Chang-Woo, Bae Soo-Kyung, Shin Jae-Gook

Abstract excerpt

OBJECTIVES: This study was conducted to compare the effect of CYP3A5*3 genotype on the disposition of three phosphodiesterase type 5 inhibitors (PDE5Is), vardenafil, sildenafil, and udenafil, because our previous in-vitro microsomal incubation study showed that the relative contribution of CYP3A5 enzyme to their metabolism was different among these PDE5Is. METHODS: An open-label three-way crossover study was...

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PMID: 21934637
DOI: 10.1097/FPC.0b013e32834b79e6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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