Article
P-selectin gene haplotype associations with albuminuria in the Diabetes Heart Study.
Kidney international - 1 Aug 2005
Liu Yongmei, Burdon Kathryn P, Langefeld Carl D, Beck Stephanie R, Wagenknecht Lynne E, Rich Stephen S, Bowden Donald W, Freedman Barry I
Abstract excerpt
BACKGROUND: Adhesion molecules, such as P-selectin, play a pivotal role in leukocyte adhesion to the endothelium during inflammation. We investigated the relationship between P-selectin gene polymorphisms and albuminuria in 565 European American siblings (84% with type 2 diabetes) from 227 families participating in the Diabetes Heart Study (DHS). METHODS: Three common missense P-selectin polymorphisms (S290N,...
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