Article
T-786C polymorphism of the endothelial nitric oxide synthase gene is associated with albuminuria in the diabetes heart study.
Journal of the American Society of Nephrology : JASN - 1 Apr 2005
Liu Yongmei, Burdon Kathryn P, Langefeld Carl D, Beck Stephanie R, Wagenknecht Lynne E, Rich Stephen S, Bowden Donald W, Freedman Barry I
Abstract excerpt
Albuminuria demonstrates significant heritability in multiply affected hypertensive and diabetic families. The role of endothelial nitric oxide synthase (eNOS) gene variants as risk factors for albuminuria was investigated in 590 European American siblings from 230 families in the Diabetes Heart Study. Two polymorphisms in the eNOS gene (T-786C in the promoter region and Glu298Asp in exon 7) were genotyped....
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