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Article

Polymorphisms of genes controlling homocysteine levels and IQ score following the treatment for childhood ALL.

Pharmacogenomics - 1 Apr 2005

Krajinovic Maja, Robaey Philippe, Chiasson Sonia, Lemieux-Blanchard Emilie, Rouillard Mélanie, Primeau Melanie, Bournissen Facundo Garcia, Moghrabi Albert

Abstract excerpt

INTRODUCTION: One of the causes of long-term morbidity associated with the treatment of acute lymphoblastic leukemia (ALL) is late neurotoxicity manifesting as impairment of higher cognitive functions. Cranial radiation therapy (CRT) and chemotherapeutic agents, particularly methotrexate (MTX), are often suggested to be major contributing factors for its development. Homocysteinemia that arises as a result of...

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Share to 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Ferredoxin-NADP Reductase

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Share to Nitric Oxide Synthase Type III

Share to Precursor Cell Lymphoblastic Leukemia-Lymphoma

Source

Identifiers

PMID: 16013960
DOI: 10.1517/14622416.6.3.293

Genes

NOS3
CBS
MTHFR
MTR
MTRR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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