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Article

Role of NADPH oxidase in the brain injury of intracerebral hemorrhage.

Journal of neurochemistry - 1 Sept 2005

Tang Jiping, Liu Jun, Zhou Changman, Ostanin Dmitry, Grisham Matthew B, Neil Granger D, Zhang John H

Abstract excerpt

The major risk factors for intracerebral hemorrhage (ICH) are hypertension and aging. A fundamental mechanism for hypertension- and aging-induced vascular injury is oxidative stress. We hypothesize that oxidative stress has a crucial role in ICH. To test our hypothesis, we used bacterial collagenase to produce ICH in wild-type C57BL/6 and gp91phox knockout (gp91phox KO) mice (deficient in gp91phox subunit of the...

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Identifiers

PMID: 16011743
DOI: 10.1111/j.1471-4159.2005.03292.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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