Article
Reverse signalling of membrane-integrated tumour necrosis factor differentially regulates alloresponses of CD4+ and CD8+ T cells against human microvascular endothelial cells.
Immunology - 1 Aug 2005
Vudattu Nalini K, Holler Ernst, Ewing Patricia, Schulz Ute, Haffner Silvia, Burger Verena, Kirchner Silvia, Andreesen Reinhard, Eissner Günther
Abstract excerpt
Reverse signalling of membrane-integrated ligands is a common phenomenon in the tumour necrosis factor (TNF) family and contributes to the pleiotropy of this pro-inflammatory cytokine and to the plasticity of the immune system in general. Transmembrane TNF (mTNF) itself can induce resistance to bacterial endotoxin in monocytes and can stimulate the immune activity of mitogen-activated, as well as of...
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